Expression of TNFSF13 in human breast cancer tissues and its clinical significance
10.11904/j.issn.1002-3070.2014.04.009
- VernacularTitle:TNFSF13在乳腺癌组织中的表达与临床意义
- Author:
Fengqin LIU
;
Yuejuan DU
;
Kun ZHOU
- Publication Type:Journal Article
- Keywords:
TNFSF13;
Breast cancer;
Prognosis
- From:
Practical Oncology Journal
2014;(4):331-336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the TNFSF13 expression and to evaluate its possible use as a potential prognostic marker in breast cancer .Methods We analyzed TNFSF13 expression by Western blot and qRT -PCR in 93 breast cancer patients .Results Our results showed that TNFSF 13 was overexpressed in breast cancer tis-sue.High TNFSF13 mRNA expression was closely correlated with tumor differentiation , pN classification ( P=0.003,0.022).In addition,patients with high TNFSF13 expression had a significantly shorter survival analyzed by Kaplan-Meier(P=0.04,log-rank test).Cox proportional hazards regression multivariable analysis revealed that high expression of TNFSF13 was identified as an independent prognostic factor (P=0.03).Conclusion TNFSF13 expression might be a novel target for prognosis and intensive therapy in breast cancer patients .
