ERCC1 expression and prognosis in non-small cell lung cancer
10.11904/j.issn.1002-3070.2014.06.009
- VernacularTitle:ERCC1在非小细胞肺癌中的表达及与临床预后的相关性
- Author:
Daming ZHOU
;
Qingfeng LU
;
Guangyu CHEN
- Publication Type:Journal Article
- Keywords:
ERCC1;
Non-small cell lung cancer;
Prognosis
- From:
Practical Oncology Journal
2014;(6):524-529
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Excision repair cross -completion 1 in non-small cell lung cancer and to analyze its clinical significance .Methods ERCC1 protein expression was detected by IHC method in 160 cases of non-small cell lung cancer tissue .We analyzed relationship between the ERCC 1 ex-pression and clinicopathological parameters of non -small cell lung cancer ,as well as its correlation between ER-CC1 expression and the prognosis .At the same time ,160 cases of intraoperative specimens were primarily cul-tured.The relationship between ERCC1 expression and the drug sensitivity of DDP was analyzed .Results ER-CC1 protein was mainly expressed in the nucleus .ERCC1 protein expression in lung cancer tissue showed no rela-tionship with age,gender,tumor size and pathological types .ERCC1 protein expression was associated with TNM stages and lymph node metastases .High expression of ERCC1was significantly correlated with poor prognosis in pa-tients,indicating that ERCC1 is the independent factor of NSCLC patients .MTT results showed that the positive ex-pression rate of ERCC1 in DDP sensitive groups was higher than in DDP resistant groups .Conclusion ERCC1 is an independent factor influencing the prognosis of non -small cell lung cancer ,and associated with DDP resistance .
