Research progress on P300/CBP in malignant tumors
10.3969/j.issn.1002-3070.2014.02.020
- VernacularTitle:P300／CBP 在恶性肿瘤中的研究进展
- Author:
Yang YANG
;
Gongyan CHEN
- Publication Type:Journal Article
- Keywords:
Lung cancer;
P300/CBP;
Signal pathway
- From:
Practical Oncology Journal
2014;(2):188-192
- CountryChina
- Language:Chinese
-
Abstract:
P300/CBP is one of the most important high molecular weight protein histone acetyltransferase ( HAT) Although it is encoded by multiple different genes , P300/CBP is highly homologous , Because they have the similar amino acid sequence and functions ,and belong to the same class of proteins ,normolly they are all called P300/CBP.P300/CBP is involved in the activation of many kinds of transcription factors ,the protein itself alsohas acetyltransferase activity ,and is capable of acetylation of 4 core histones and transcription factor .More and more studies have confirmed the relationship of P 300/CBP variation withmultiple human diseases , including in-flammation,diabetes,heart disease and especially cancer .In tumor P300/CBP is associated with some pathways , and these pathways play a different roles in the tumor .Although P300/CBP is usually regarded as a tumor sup-pressor factor ,is plays different roles in different tumors ,This review mainly introduces the relationship of P 300/CBP with some solid tumor disease genes ,related transcription factors and their signaling pathways .
