The expression and signi ficance of ING3 in colorectal cancer
10.11904/j.issn.1002-3070.2014.06.001
- VernacularTitle:抑癌基因 ING3在大肠癌中表达及意义
- Author:
Binbin CUI
;
Yanlong LIU
;
Hongsheng CHEN
;
Fei ZHOU
;
Xuefeng YU
;
Haitao XU
- Publication Type:Journal Article
- Keywords:
Tumor suppressor gene;
ING3;
Colorectal cancer
- From:
Practical Oncology Journal
2014;(6):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Objetcvi e Inhibitor of growth TNG3 is a candidate tumor suppressor gene ,which belongs to the human ING gene family .It has been interested by scientist because of its putative roles as tumor suppressors . There is a low expression level of ING3 in a variety of tumors.However,the relationship of ING3 and the develop-ment of colorectal cancer is unclear yet .The aim of this studyis to examine the expression of ING 3 in colorectal cancer by qRT-PCR.Methods Statistical analysis was performed with the expression of ING 3 mRNA which has been evaluated in 82 matched samples comprising primary colorectal cancer and paired non -cancerous mu-cosa samples.Results In 51%colorectal cancer patients ,the expression level of ING3 was significantly lower in cancer tissue than that in normal tissue .The expression level of ING3 was closely related to pT、pM stage , and TNM stage(P<0.05).The Univariate analysis showed that the pT、pN、pM stage,TNMstage and ING3 expression levels were associated with disease -free survival(P<0.05).CRC patients with low -expression level of ING3 showed shorter disease -free survivals(P<0.05).Conclusion The expression of ING3 might contribute to the CRC development or progression .
