Research progress of HIF-1 in cancers
10.11904/j.issn.1002-3070.2014.06.018
- VernacularTitle:HIF －1与肿瘤相关性研究进展
- Author:
Bo ZHANG
;
Gang ZHAO
- Publication Type:Journal Article
- Keywords:
Hypoxia;
HIF-1;
Neoplasms
- From:
Practical Oncology Journal
2014;(6):565-568
- CountryChina
- Language:Chinese
-
Abstract:
Transcription factorhypoxia inducible factor -1(HIF-1)plays a key role in cell adaption to hypoxia(from 21%O2 to 1%O2).Researches have shown that HIF -1 is closely related to occurrence and de-velopment in many malignant cancers .In this paper,we review the effect of HIF -1 in tumor growth,metastasis, apoptosis and angiogenesis .
