Related research of male breast cancer and CAG repeat polymorphism of AR gene

VernacularTitle:男乳癌与 AR 基因 CAG 重复多态性的相关性研究
Author: Jialin CUI ; Rui HUANG ; Yongdong JIANG ; Jiguang HAN ; Ming NIU ; Wei WEI ; Wei ZHENG ; Yanni SONG
Publication Type:Journal Article
Keywords: Male breast cancer; Androgen receptor; CAG repeat sequence; Polymorphic
From: Practical Oncology Journal 2015;(6):492-496
CountryChina
Language:Chinese
Abstract: Objectiv e To investigate the correlation between ( CAG) n repeat polymorphism of androgen receptor(AR)geneandmalebreastcancer.Methods 40casesofmalebreastcancerand40controlswerecol-lected.DNA was extracted from peripheral blood and the AR gene CAG coding exon sequences for PCR amplifica -tion,sequencing and calculated the number of CAG repeats frquency .χ2 test and Logistic regression analysis were used assess the AR gene CAG repeat length frequency affect the number of male breast cancer risk .Results There was statistically significant difference in male breast cancer cases and controls the number of CAG repeat length frequency.Man for whom the(CAG)n≥22 repeat sequence had 3.52 times risk of male breast compared (CAG)n≤22(OR=3.52,P=0.036).Conclusion AR gene CAG repeat length is a predictor of the frequency of male breast cancer risk .Longer CAG repeats can increase the risk of male breast cancer .