Value of diffusion weighted magnetic resonance imaging in the monitoring of neoadjuvant chemotherapy efficacy for uterine cervical cancer
10.11904/j.issn.1002-3070.2015.06.008
- VernacularTitle:MRI 弥散加权成像对宫颈癌新辅助化疗评估的应用价值
- Author:
Zhichang BA
;
Xinxin WANG
;
Wanhui CUI
;
Fei GUO
;
Xiushi ZHANG
- Publication Type:Journal Article
- Keywords:
Magnetic resonance lmaging ( MRI );
Diffusion weighted imaging;
Uterine cervix cancer;
Neoadjuvant chemotherapy
- From:
Practical Oncology Journal
2015;(6):518-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the value of diffusion weighted imaging ( DWI) in assessing the effect of neoadjuvant chemotherapy of uterine cervix cancer .Methods Thirty one patients with LACC confirmed by pa-thology received conventional magnetic resonance imaging and DWI before and after neoadjuvant chemotherapy . The variation of DWI image and ADC was evaluated before and after chemotherapy .Results The correlation be-tween maximum diameter of the tumor before treatment (37.10 ±11.23) and pretreatment ADC value (0.83 ± 0.12)was not statistically significant(correlation coefficient r=-0.1746,P=0.3475);the correlation between the maximum diameter of the tumor(24.03 ±5.65)and ADC value(1.10 ±0.16)after treatment was not statisti-cally significant(correlation coefficient r=-0.2077,P=0 2621.);the degree of tumor size before and after the treatment was correlated with the degree of ADC increase (P<0.05);Effective chemotherapy group of 20 cases, invalid group of 11 cases,ADC value of effective treatment group after treatment (0.95 ±0.13) was significantly higher than ADC value before chemotherapy (0.80 ±0.12),the change was statistically significant (P<0.05), while the difference between former ADC value(0.88 ±0.10)and ADC value after treatment(0.95 ±0.13)of in-effective group therapy was not statistically significant (P>0.05).Conclusion DWI sequence may be useful for early prediction and evaluation of curative effect to neoadjuvant chemotherapy for uterine cervical cancer .
