The research progress of LSD1 in malignant tumors
10.11904/j.issn.1002-3070.2014.06.019
- VernacularTitle:LSD1在恶性肿瘤中的研究进展
- Author:
Jing JING
;
Gongyan CHEN
- Publication Type:Journal Article
- Keywords:
LSD1;
Demethylation;
Malignant tumors
- From:Practical Oncology Journal
2014;(6):569-572
- CountryChina
- Language:Chinese
-
Abstract:
Lysine specific demethylase 1( LSD1) is a kind of flavin adenine dinucleotid ( FAD) dependent amine oxidase and can specifically demethylate H 3K4me2/me1 and H3K9me2/mel, thus it can regulate gene transcriptional activity .LSD1 is essential for mammalian development and is involved in many biological proces-ses,including cell differentiation,gene activation,and gene repression.Nowadays,it is demonstrated that LSD1 might promote cell phase transition(deficiency in LSD1 leads to partial cell cycle arrest in G2/M)and cell prolif-eration,suggesting that the over -expression of LSD1 might promote tumorigenesis.LSD1,as a demethylase,may be a new target for anti -cancer therapy.Hereby,we review on the structure,action mode of LSD1 and its rela-tionship with oncogenesis .
