Advanced research on characteristics of the classical subtype of human glioblastoma
10.11904/j.issn.1002-3070.2015.02.009
- VernacularTitle:胶质母细胞瘤经典亚型特征性基因变异的研究进展
- Author:
Enrui LIU
;
Huan REN
;
Yu ZHAO
;
Jun SU
- Publication Type:Journal Article
- Keywords:
Glioblastoma;
Molecular classification;
Genetic alteration;
Classical glioblastoma;
Molecular targeted therapy
- From:
Practical Oncology Journal
2015;(2):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma(GBM)is one of the most common primary intracranial tumor that has high de-gree of malignancy ,invasive ability and a fatal prognosis .In recent years ,with the development of modern technol-ogy in biomedical sciences ,the understanding on GBM has developed gradually from pathological diagnosis to mo -lecular classifications ,which is based on the molecular characteristics of genetic signatures .Based on gene expres-sion and DNA methylation patterns , primary glioblastoma is divided into four subtypes , including the classical , neural,proneural and mesenchymal .These molecular classifications are closely relevant to the biological charac-teristics of glioblastoma .This review briefly introduces the molecular classifications of primary glioblastoma , but mainly focuses on the changes of the major genetic EGFR ,PTEN and PI3K,CDKN2A in the classical subtype of GBM,and discusses the treatment strategies for primary glioblastoma .
