Allogeneic hematopoietic stem cell transplantation followed by donor derived lymphocyte and EBV specif-ic cytotoxic T-lymphocyte immunotherapy for hydroa vacciniforme-like lymphoma:A case report and literature review

VernacularTitle:异基因造血干细胞移植联合供者源淋巴细胞及EBV特异性杀伤T细胞治疗种痘水疱样淋巴瘤一例报告及文献复习
Author: Shuna XU ; Lihui LIU ; Yongqing ZHANG ; Wenqing HU
Publication Type:Journal Article
Keywords: Hdroa vacciniforme -like lymphoma; Hematopoietic stem cell transplantation; EBV-spe-cific cytotoxic T-lymphocyte
From: Practical Oncology Journal 2015;(6):533-535
CountryChina
Language:Chinese
Abstract: The hydroa vacciniforme -like lymphoma is clinically manifested by rash ,fever,hepatospleno-megaly and lymphadenectasis .Pathological character showed that lymphocytes infiltrated into dermis and there were some heterocysts.Immunohistochemistory showed that Bcl -6,Bcl -2,CD3,CD8,TIA,CD4,granzyme, EBER were positive,CD56,CD20 all tested negative.The rearrangement of TCR of bone marrow cell was positive . The hydroa vacciniforme-like lymphoma is uncommon clinically ,and it is easy to misdiagnosed .The effect of tra-ditional therapy is poor ,while the allogeneic hematopoietic stem cell transplantation followed by lymphocyte and donor-derived EBV-specific cytotoxic T -lymphocyte immunotherapy is effective ,which may offer an curable therapy for HVLL.