The si gnificances tumor abnormal p rotein detection for diagnosis and prediction of prognosis in gastroin-tetsinal tumors
10.11904/j.issn1.002-3070.2015.02.006
- VernacularTitle:TAP 检测在消化道肿瘤诊断和预后判断中的意义
- Author:
Songyuan YAO
;
Yongmei WU
- Publication Type:Journal Article
- Keywords:
Tumor abnormal protein;
Detection;
Gastrointestinal tumor;
Early diagnosis;
Incidence
- From:Practical Oncology Journal
2015;(2):122-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possibility of tumor abnormal protein ( TAP) ,as index of diag-nosis and prediction of prognosis in gastrointestinal tumors (GITs).Methods The outpatients and inpatients as well as healthy physical examinees in our hospital were chosen as objects in the present study .The patients were divided into GIT group(120 cases),high-risk GIT group(123 cases)and normal group(117 cases).TAP ex-pression was detected in three groups.These study objects were followed up for one and a half years .Then the re-lationship between TAP expression and the occurrence or recurrence of tumors was analyzed .Rseults There were significant differences(P<0.001)among the three groups on the positive TAP with critical expression rate .TAP detections to GITs diagnosis sensitivity ,specificity ,positive predictive value ,negative predictive value and Youden index were 88.33%,85.83%,75.71%,93.64% and 0.74 respectively.TAP positive non GITs crowd tumori-genesis proportion (23.53%)was significantly higher than that of TAP -negative(0.49%)(P<0.001).GITs TAP positive patients relapse rate(33.33%)was significantly higher than negative ones (6.90%)(P<0.001). Conlcusion TAP can be an index for diagnosis ,early prevention ,monitoring of treatment effect and prediction of prognosis of gastrointestinal tumor .
