Progress in long non-coding RNA of colorectal cancer
10.11904/j.issn.1002-3070.2015.06.016
- VernacularTitle:结直肠肿瘤中长链非编码 RNA 的研究进展
- Author:
Yongjian ZHANG
;
Yanlong LIU
;
Binbin CUI
- Publication Type:Journal Article
- Keywords:
Long non-coding RNA(LncRNA);
Colorectal cancer;
Gene regulation
- From:
Practical Oncology Journal
2015;(6):553-556
- CountryChina
- Language:Chinese
-
Abstract:
Many long non -coding RNA ( lncRNA ) has been found in recent years .The abnormal ln-cRNA expression is closely related to the occurrence and development of tumor .LncRNA can be divided into the tumor promoting and tumor inhibiting according to the function .lncRNA generally overexpresses in solid tumor tis-sue,acts as an important factor involved in tumor invasion ,proliferation and metastasis ,and has been associated with prognosis of neoplasm .This paper describes the current situation of lncRNA research .We mainly introduce several functions of lncRNA which thoroughly researched at present (such as HOTAIR,H19,MALAT-1,Lin-cRNA-p21,GAS5,etc) and their expression in colorectal tumor tissue ,indicating that regulating the expression level of lncRNA may provide a new basis for the diagnosis and treatment of colorectal cancer .
