The experimental progress on arsenic trioxide for non-APL and solid tumor
10.11904/j.issn.1002-3070.2015.02.011
- VernacularTitle:三氧化二砷对非急性早幼粒细胞白血病和实体瘤的实验研究进展
- Author:
Maiyu ZHOU
;
Zhuo ZHANG
;
Jin ZHOU
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Non-APL leukemia;
Solid tumor
- From:
Practical Oncology Journal
2015;(2):144-148
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic trioxide(As2O3)effectively triggers apoptosis in acute promyelocytic leukemia (APL) cells and induces complete remission and cure in most APL patients ,if they can refrain from early mortality .In the last few years,it has been under investigation as a potential treatment for non -APL leukemia and a variety of sol-id tumors.In the meantime,it has been found that As2O3 also inhibits proliferation of non -APL leukemia cell and several solid tumor cell such as liver ,esophageal ,and gastric cancer cell in vitro or in vivo in the more and more studies .The molecular mechanisms that As 2 O3 induces cellular apoptosis in non APL leukemia cell and solid tumor cells have been discussed ,which also includes building new targeting preparation in order to obtain much more satisfying therapeutic effect and relieve its cellular toxic and side effect and so on.Here, we give a summary which is connected with the research progress above .
