Advances in pulmonary fibrosis caused by thoracic radiotherapy combined with EGFR-TKIs
10.11904/j.issn.1002-3070.2015.02.015
- VernacularTitle:胸部放疗联合 EGFR －TKIs 致肺纤维化的研究进展
- Author:
Qian ZHANG
;
Wenbo QIAO
- Publication Type:Journal Article
- Keywords:
Thoracic radiotherapy;
EGFR-TKIs;
Pulmonary fibrosis
- From:
Practical Oncology Journal
2015;(2):162-166
- CountryChina
- Language:Chinese
-
Abstract:
Thoracic radiotherapy is an important means of local treatment for non -small cell lung cancer (NSCLC).Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)have the effect of systemic therapy.Studies have shown that NSCLC patients with EGFR exons 19,21 mutation have a synergistic effect in the combination therapy .Radiotherapy activates EGFR signaling pathway ,inducing cell proliferation and DNA damage repair,leading to radiation resistance .Therefore,EGFR-TKIs have the effect in increasing radiosensitivity .Lung injury is one of the most common side effects when the two therapies combined .Studies suggest that radiotherapy combined with EGFR-TKIs may have conflicting functions in the development of pulmonary fibrosis ,the discrep-ancy between these studies may depend on the differences in the experimental systems ,the differences in pulmo-nary fibrosis models,as well as the differences between different species and individuals .Therefore,a more com-plete understanding of the etiology for pulmonary fibrosis is necessary to the development of improved treatments .
