Improving understanding of liver immune function and enhancing research on cell therapy for liver diseases
10.3969/j.issn.1001-5256.2014.09.001
- VernacularTitle:提高肝脏免疫功能认知，加强肝病细胞治疗研究
- Author:
Zhansheng JIA
;
Jianqi LIAN
- Publication Type:Journal Article
- Keywords:
liver diseases;
immuity;
cell therapy;
editorial
- From:
Journal of Clinical Hepatology
2014;30(9):839-841
- CountryChina
- Language:Chinese
-
Abstract:
As an important immune organ,the liver has a unique immune microenvironment,and is one of the important places for innate immunity and adaptive immunity.The liver is closely connected with the immune system through the gut-liver axis and is also the target or-gan of immune injury.However,the defensive role of the liver for Hepadnaviridae remains unclear.Cell therapy for liver diseases includes input of liver cells or stem cells for functional replacement,therapy by immune cells for antiviral and antitumor purposes,and genetic therapy for hereditary hepatopathy with cells as the carrier.The features of mesenchymal stem cells,multi-directional differentiation potential and immunomodulatory property,become the hot spots of cell therapy for liver diseases,and efficient in vitro amplification of cells makes it possi-ble for the use of NK cells in the treatment of hepatocellular carcinoma.
