Persistent hepatitis virus infection and immune homeostasis
10.3969/j.issn.1001-5256.2014.09.004
- VernacularTitle:持续性HBV或HCV感染与免疫稳态
- Author:
Yun ZHOU
;
Jianqi LIAN
;
Zhansheng JIA
- Publication Type:Journal Article
- Keywords:
hepatitis viruses;
immune system;
allostasis
- From:
Journal of Clinical Hepatology
2014;30(9):851-854
- CountryChina
- Language:Chinese
-
Abstract:
Homeostasis between the host and viruses is naturally maintained.On the one hand,the immune system activates the immune re-sponse to kill or eliminate viruses;on the other hand,the immune system controls the immune response to maintain immune homeostasis. The cause of persistent infections with hepatitis viruses such as HBV and HCV is that viral molecules damage the immune system of the host and their variants escape immune clearance.Long-term coexistence of the host and viruses is the process involving various immune cells and molecules and is the result of homeostasis maintenance in antiviral immune response.The immune homeostasis maintained during persis-tent infections with hepatitis viruses is analyzed by the cellular and molecular mechanisms.
