Observation on the efficiency and safety of Entecavir on chronic hepatitis B
- VernacularTitle:恩替卡韦治疗慢性重型乙型肝炎疗效观察
- Author:
Zhiqi HAN
;
Bo QIN
;
Hai ZHANG
- Publication Type:Journal Article
- Keywords:
Entecavir;
HBV;
chronic severe hepatitis
- From:
Journal of Clinical Hepatology
2009;25(3):188-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficiency and safety of Extecavir on chronic severe hepatitis B.Methods 36 patients with chronic severe hepatitis B were randomly divided into 2 groups. Control group (n=16) was given the conventional therapy. Treatment group (n=20) was treated with Entecavir, 0.5mg daily for four weeks, on the bases of routine treatment. Before and after treatment, hepatic function, prothrombin active (PTA), HBVDNA and efficiency rate of the two groups were detected.Results the results showed that the total efficiency rates of treatment group and control group were 85% and 50% respectively. There was significant difference between the two groups (P<0.01). After treated for four weeks, the improvement of TBil and PTA effect was observed.Conclusion It can be concluded that Entecavir has good therapeutic efficiency and safety in the treatment of chronic severe hepatitis B.