Significance of changes in hepatic histology from patients with HBeAg(+)or HBeAg(-)chronic hepatitis B and normal or mildly elevated alanine aminotransferase

VernacularTitle:ALT正常或轻度升高的HBeAg阳性和阴性慢性乙型肝炎肝组织学变化的再关注
Author: Lin LAN ; Yin KONG ; Lingyi ZHANG
Publication Type:Journal Article
Keywords: hepatitis B,chronic; hepatitis B e antigens; alanine transaminase; histology
From: Journal of Clinical Hepatology 2015;31(4):510-513
CountryChina
Language:Chinese
Abstract: Alanine aminotransferase (ALT)abnormality is an indicator of the degree of liver inflammation caused by immune activation in patients with chronic hepatitis B (CHB).However,approximately half of the CHB patients with normal or mildly elevated ALT levels have concealed significant changes in hepatic histology.CHB patients with normal or mildly elevated ALT levels may have significant histopatho-logical changes in hepatic tissues,and those changes vary between HBeAg(+)and HBeAg(-)CHB patients.Attention and investigation on the clinical management of CHB patients with normal or mildly elevated ALT levels may have great significance in grasping the right treat-ment opportunity and reducing the risk of liver cirrhosis.