Role of cancer-associated fibroblasts in growth and metastasis of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2014.09.007
- VernacularTitle:肿瘤相关成纤维细胞在肝细胞癌生长和转移中的作用
- Author:
Dening MA
;
Xiaodong ZHU
;
Zhaoyou TANG
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
fibroblasts;
tumor microenvironment;
review
- From:
Journal of Clinical Hepatology
2014;30(9):865-868
- CountryChina
- Language:Chinese
-
Abstract:
The development and progression of tumors are closely related to the tumor microenvironment.As one of the most important com-ponents in tumor microenvironment,cancer-associated fibroblasts (CAFs)play an important role in carcinogenesis,angiogenesis,inva-sion,and metastasis of tumors.The role of CAFs in the development and progression of hepatocellular carcinoma (HCC)is reviewed by dis-cussing how CAFs are recruited and activated in the tumor microenvironment and how CAFs promote tumor angiogenesis and regulate tumor immunity.This review may provide new approaches for the treatment of HCC.
