Research advances in predictors of treatment responses to pegylated interferon alpha in patients with chronic hepatitis B
10.3969/j.issn.1001-5256.2015.04.029
- VernacularTitle:聚乙二醇干扰素α对慢性乙型肝炎患者治疗应答相关因素的研究进展
- Author:
Aihua GAO
;
Yuguo ZHANG
;
Yuemin NAN
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
interferon alpha;
review
- From:
Journal of Clinical Hepatology
2015;31(4):594-598
- CountryChina
- Language:Chinese
-
Abstract:
The treatment responses to pegylated interferon alpha (PEG-IFNα)in patients with chronic hepatitis B (CHB)are associated with the genetic polymorphisms,immune status,hepatitis B virus genotype,and viral load of the host.This article reviews the recent studies on influential factors for the responses to PEG-IFNαin CHB patients.The important predictors of the clearance and seroconversion of HB-sAg and HBeAg and sustained virological response include interleukin-28B (IL-28B)gene polymorphism,baseline level of interferon-inducible protein-10,IL-17A,IL-10,tumor necrosis factor-α,viral load and genotype,and changes in serum HBsAg and HBeAg levels at weeks 12 and 24 of treatment.
