Role of interleukin-1 0 in prognosis of hepatitis B virus infection
10.3969/j.issn.1001-5256.2015.04.035
- VernacularTitle:白细胞介素10水平与HBV感染转归及预后的关系
- Author:
Changhui WU
;
Jia WEI
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
interleukin-10;
polymorphism,single nucleotide;
prognosis;
review
- From:
Journal of Clinical Hepatology
2015;31(4):618-621
- CountryChina
- Language:Chinese
-
Abstract:
Multiple etiological factors are integrally involved in the development of hepatitis B virus (HBV)infection.Interleukin-10 (IL-10)is an essential cytokine of immune regulation,and IL-10 gene promoter polymorphism affects its mRNA transcription and serum level. IL-10 is related to the prognosis of HBV infection.This review briefly discusses the association of IL-10 gene polymorphism and its serum level with the prognosis of HBV infection,and summarizes the role of IL-10,as an anti-inflammatory cytokine,in host immune function, the prognosis and progression of HBV infection,and HBV-related complications.IL-10 gene polymorphism and its serum level are closely associated with inflammatory response after HBV infection,influence HBV clearance,and are related to the severity of HBV-related liver injury,liver cirrhosis,and hepatocellular carcinoma.The determination of IL-10 gene and serum levels may provide a predictive marker for the prognosis of HBV infection.
