Immune -mediated liver failure
10.3969/j.issn.1001-5256.2014.10.004
- VernacularTitle:肝衰竭的免疫发病机制
- Author:
Xiaojing WANG
;
Xiaoping ZHANG
;
Qin NING
- Publication Type:Journal Article
- Keywords:
liver failure;
immunity,natural;
immunity,active;
cytokines;
death domain receptor signaling adaptor proteins
- From:
Journal of Clinical Hepatology
2014;30(10):984-991
- CountryChina
- Language:Chinese
-
Abstract:
The primary causative factors of liver failure include direct damage and immune -mediated liver injury.Increasing evidence sug-gests that immune -mediated injury plays a pivotal role in the pathogenesis of liver failure.The new concepts concerning the mechanisms of immune -mediated liver injury in liver failure are reviewed with relevant basic and clinical studies in both humans and animals.The innate and adaptive immunity,particularly the interaction of various immune cells and molecules,as well as apoptosis -related molecules,are dis-cussed in detail.
