Roles of epithelial cell adhesion molecule in diagnosis and treatment of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2015.04.039
- VernacularTitle:上皮细胞黏附分子在肝细胞癌诊疗中的作用
- Author:
Minna ZHANG
;
Yongping YANG
;
Panyong MAO
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
epithelial cell;
cell adhesion molecules;
diagnosis;
therapy;
review
- From:
Journal of Clinical Hepatology
2015;31(4):635-638
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial cellular adhesion molecule (EpCAM)is a transmembrane glycoprotein expressed in epithelial tissues and most epitheli-al-derived malignant tumors.EpCAMis associated with cell adhesion,migration,proliferation,and differentiation,as well as tumor devel-opment and progression.In recent years,EpCAMhas been identified as a stem cell marker of hepatocellular carcinoma (HCC).This paper elucidates the roles of EpCAMin the diagnosis,treatment,and prognosis of HCC,which shed light on the potential molecular targeted thera-py in future.
