Recent advances in pathogenesis and management of pruritus in cholestatic liver disease
10.3969/j.issn.1001-5256.2014.11.031
- VernacularTitle:胆汁淤积性肝病并发皮肤瘙痒的发病机制及治疗进展
- Author:
Man WANG
;
Fengxia SUN
- Publication Type:Journal Article
- Keywords:
cholestasis;
liver diseases;
pruritus;
review
- From:
Journal of Clinical Hepatology
2014;30(11):1208-1211
- CountryChina
- Language:Chinese
-
Abstract:
Pruritus is one of the common clinical manifestations of cholestatic liver diseases such as primary biliary cirrhosis,primary scle-rosing cholangitis,and intrahepatic cholestasis of pregnancy.Potential incentives of itching include bile salts,histamine,progesterone me-tabolites,endogenous opioid substances,and lysophosphatidic acid,according to previous studies.However,the exact pathogenesis of chol-estatic pruritus remains unclear,and the current treatment can only alleviate the symptoms in some of the patients.Novel methods for treating pruritus have been proposed and/or are being studied.The recent experimental and clinical studies on the pathogenesis and treatment of pru-ritus in cholestatic hepatitis are reviewed,in order to improve the understanding and management of cholestatic pruritus.
