Application of CRISPR/Cas9 system in virus research
10.3969/j.issn.1001-5256.2016.01.041
- VernacularTitle:成簇的规律间隔短回文重复序列/Cas9系统在病毒领域的应用
- Author:
Qingfen ZHENG
;
Zhongping DUAN
;
Jiansheng LI
- Publication Type:Journal Article
- Keywords:
virus;
RNA editing;
review
- From:
Journal of Clinical Hepatology
2016;32(1):185-187
- CountryChina
- Language:Chinese
-
Abstract:
To date,the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system has been widely used to edit the genome in many species and cells.The system is the third generation of artificial endonuclease,which can edit DNA by recognizing short DNA sequences.This paper reviews the structural features of the system and its application in virus research,such as the functional studies of virus-related genes and the exploration of antiviral therapies (including HIV,HBV,and EB virus),looking forward to the future direc-tion of virus research.
