Role of hepatic sinusoids in lipopolysaccharide-induced liver injury
10.3969/j.issn.1001-5256.2016.01.040
- VernacularTitle:肝血窦在内毒素致肝损伤中的作用
- Author:
Lili ZHAO
;
Dongya YUAN
;
Fangyun SUN
- Publication Type:Journal Article
- Keywords:
liver diseases;
lipopolysaccharides;
kupffer cells;
review
- From:
Journal of Clinical Hepatology
2016;32(1):182-184
- CountryChina
- Language:Chinese
-
Abstract:
Endotoxin,which is also called lipopolysaccharide (LPS),is a unique element of Gram-negative bacteria.Liver is the main site for removing bacteria and endotoxin.Meanwhile,it is also the most vulnerable organ.Liver injury initially occurs in the hepatic sinu-soids.This article mainly introduces the impact of LPS on Kupffer cells,hepatic sinusoidal endothelial cells,oxidant/antioxidant balance in the hepatic sinusoids,and liver blood flow.It is believed that the function of hepatic sinusoids in LPS-induced liver injury should not be ig-nored,and the hepatic sinusoids would play an important role in the prevention and treatment of LPS-induced liver injury.
