Liver fibrosis of chronic HBV infected patients older than 40-year-old with normal ALT
- VernacularTitle:大于40岁ALT正常慢性HBV感染者肝组织纤维化分期的研究
- Author:
Jing LI
- Publication Type:Journal Article
- Keywords:
HBVDNA;
ALT;
HBeAg;
hepatic histopathology
- From:
Journal of Clinical Hepatology
2009;25(3):182-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the stages of liver fibrosis in patients aged older than 40 with normal ALT.Methods 84 patients with chronic HBV infected were investigated in this study. Liver function, HBeAg, HBVDNA, serum liver fibrosis indexes were tested. And liver biopsy was taken in all the patients and the tissues were stained with HE and Masson.Results 73.4% patients were at fibrosis stage 2-4. The serum fibrosis indexes correlated with the fibrosis stage of liver histology. While the levels of HBeAg and HBVDNA didn't correlate with the severity of liver fibrosis.Conclusion Liver fibrosis of patients older than 40-year-old should be analyzed synthetically with many clinical indexes. These patients should be administered with antifibrosis therapy to prevent the progression of liver cirrhosis.
