Research progress in role of B cell immunity in primary biliary cirrhosis
10.3969/j.issn.1001-5256.2014.05.004
- VernacularTitle:原发性胆汗性肝硬化中B细胞免疫的研究进展
- Author:
Yanguo TAN
;
Huiping YAN
;
Zuhua GAO
- Publication Type:Journal Article
- Keywords:
liver cirrhosis,biliary;
immunity,humoral;
B lymphocytes;
review
- From:
Journal of Clinical Hepatology
2014;31(5):400-404
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cirrhosis (PBC)is characterized by injury of small intrahepatic bile ducts,but its mechanism,especially the role of B cell immunity in this disease,remains unclear.The possible role of B cell immunity in the pathogenesis of PBC is reviewed from the fol-lowing aspects:distribution of B cells and plasma cells in the liver tissues of PBC patients,clearance of B cells,mechanism of abnormal in-crease in serum IgM and its sources among PBC patients,mechanism of production of antimitochondrial antibodies and their possible func-tions in bile duct injury,and typical autoantibodies in PBC.B cell immunity is considered to play a significant role in the pathogenesis of PBC,but there are still many key problems to be clarified.
