Significance of clinical pathology in diagnosis and treatment of autoimmune liver diseases
10.3969/j.issn.1001-5256.2014.05.001
- VernacularTitle:临床病理学在自身免疫性肝病诊治中的重要性
- Author:
Qi MIAO
;
Xiong MA
- Publication Type:Journal Article
- Keywords:
autoimmune diseases;
liver disease;
pathology clinical;
histology;
editorial
- From:
Journal of Clinical Hepatology
2014;31(5):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Liver biopsy plays an important role in the diagnosis of autoimmune liver diseases,particularly in patients without specific clinical manifestations or negative for autoantibodies.The histological features of several autoimmune liver diseases are reviewed.The characteristic features of autoimmune hepatitis in histology include interface hepatitis with lymphoplasmacytic infiltration,hepatic rosette formation,and emperipolesis,while chronic nonsuppurative destructive cholangitis and epithelioid granuloma are frequently found in primary biliary cirrho-sis.Primary sclerosing cholangitis is characterized by onion skin-like periductal fibrosis,while storiform fibrosis with IgG4-positive plas-ma cell infiltration often indicates IgG4 -related sclerosing cholangitis.Enhanced communication between clinicians and pathologists can help improve the diagnosis and treatment of autoimmune liver diseoses.
