Main methods of computational pharmacology and their application in research on traditional Chinese medicine pre-scriptions for treating chronic liver diseases
10.3969/j.issn.1001-5256.2014.04.001
- VernacularTitle:计算机药理学的主要方法及其在中医方药治疗慢性肝病研究中的应用
- Author:
Wenwei FU
;
Hua ZHANG
;
Ping LIU
- Publication Type:Journal Article
- Keywords:
liver diseases;
TCM THERAPY;
computational pharmacology;
editorial
- From:
Journal of Clinical Hepatology
2014;31(4):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine (TCM)has certain advantages in the treatment of chronic liver diseases,especially chronic inflam-matory injury and liver fibrosis.However,the studies on medicinal components and action mechanism of TCM prescriptions are confronted with a great challenge.The computational pharmacology methods used in recent years,mainly including virtual screening technique,omics technologies,and network pharmacology approaches,as well as their application in TCM research,are presented;given the previous re-search work,the progress in research on active ingredients and action mechanism of TCM prescriptions using computational pharmacology methods is reviewed.It is thought that computational pharmacology techniques combined with conventional molecular biological and pharma-cological methods are an important research strategy for the material basis and action mechanism of TCMprescriptions for treating chronic liv-er diseases.
