The challenges to hepatitis C research in era of direct antiviral agents
10.3969/j.issn.1001-5256.2014.06.001
- VernacularTitle:直接抗病毒药物时代下丙型肝炎研究面临的挑战
- Author:
Jin ZHONG
;
Wanyin TAO
- Publication Type:Journal Article
- Keywords:
hepatitis C;
direct antiviral agents;
review
- From:
Journal of Clinical Hepatology
2014;30(6):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis C virus (HCV)is an important human pathogen that causes chronic viral hepatitis worldwide.HCV infection,often persistent and asymptomatic,could lead to liver fibrosis/cirrhosis and hepatocellular carcinoma.The interferon/ribavirin therapy has been widely used for treating chronic hepatitis C,but it is not always effective and has strong side effects.The development of small-molecule di-rect antiviral agents (DAA)has greatly improved the curing efficiency of chronic hepatitis C therapeutics and will likely replace the interfer-on-based therapy in the future.However,these developments do not necessarily suggest that the problems of chronic hepatitis C have been completely solved.The HCV research is still facing many challenges in this new DAA era.
