Therapeutic efficacy of Ganshuang granules in treatment of hepatic fibrosis
10.3969/j.issn.1001-5256.2014.04.008
- VernacularTitle:肝爽颗粒联合阿德福韦酯治疗肝纤维化的疗效分析
- Author:
Fengxiao ZHANG
;
Xuesong BAI
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
liver cirrhosis;
Gan-shuang granules;
adefovir dipivoxil
- From:
Journal of Clinical Hepatology
2014;31(4):317-319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic efficacy of Ganshuang granules in the treatment of hepatic fibrosis.Methods Sixty-eight patients with cirrhosis due to chronic hepatitis B (CHB)were divided into experimental group (n=34)and control group (n=34).Both groups received adefovir dipivoxil for 6 months,and the experimental group received Ganshuang granules additionally for 24 weeks.After treat-ment,the changes in hepatic fibrosis indices including hyaluronic acid (HA),laminin (LN),collagenⅣ(CⅣ),and precollagenⅢ(PCⅢ),as well as liver stiffness value were evaluated by paired t test.Results In the experimental group,the serum levels of HA,LN,CⅣ, and PCⅢwere significantly decreased by 37.5%,34.2%,35.4%,and 39.9%,respectively (t=2.238,2.151,2.148,and 2.198,P<0.05 for all),and the liver stiffness value was significantly cut by 40.6%(t=2.189,P<0.05).However,the control group showed no sig-nificant changes in these indices.Conclusion For patients with cirrhosis due to CHB,Ganshuang granules can effectively reduce serum mark-ers of hepatic fibrosis and liver stiffness value and have a good therapeutic efficacy in the treatment of hepatic fibrosis.
