Research advances in microRNAs in regulating hepatitis C virus replication and antiviral therapy
10.3969/j.issn.1001-5256.2015.05.042
- VernacularTitle:宿主 microRNAs 在 HCV 复制及搞 HCV 治疗中的作用
- Author:
Xianghua CUI
;
Jidong JIA
- Publication Type:Journal Article
- Keywords:
hepacivirus;
microRNA;
antiviral agents;
review
- From:
Journal of Clinical Hepatology
2015;31(5):800-802
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis C virus (HCV)infection is one of the most common causes of chronic hepatitis,liver cirrhosis,and hepatocellular car-cinoma.MicroRNAs (miRNAs),a class of small,non -coding RNA,are involved in a variety of physiological and pathological processes in human bodies.The mechanism by which miRNAs regulate HCV replication is described,and the effects of liver -specific microRNA -122 antagonists on hepatitis C antiviral therapy are discussed.Our study indicates that miRNAs play an important regulatory role in HCV ex-pression.Targeting miRNAs may be a potential therapeutic approach for treating HCV infection,but further studies are still in need.
