Significance of serum anti-gp210 antibody detection in diagnosis of primary biliary cirrhosis
10.3969/j.issn.1001-5256.2014.05.023
- VernacularTitle:原发性胆汗性肝硬化患者血清抗gp210抗体检测的意义
- Author:
Yinping LI
;
Junqi NIU
- Publication Type:Journal Article
- Keywords:
liver cirrhosis,biliary;
anti gp210 antibody;
review
- From:
Journal of Clinical Hepatology
2014;31(5):466-468
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cirrhosis (PBC)is a chronic disease characterized by progressive destruction of intrahepatic small bile ducts, which may progress to liver cirrhosis.Anti-mitochondrial antibodies,especially anti-M2 antibody,have a high diagnostic value for PBC, but they are unrelated to the severity and prognosis of the disease and are negative in some patients.There have been reports from around the world that anti-nuclear antibodies,especially anti-gp210 antibody,are closely associated with PBC.It showed that anti-gp210 antibody has high specificity and sensitivity for the diagnosis of PBC,especially for the patients with negative anti-M2 antibody tests;in addition,it has a high predictive value for the prognosis and development model of the disease.Anti -gp210 antibody has a high diagnostic value for PBC,with great clinical significance,so its detection holds promise for clinical application.
