Pathogenetic mechanism of microcirculatory disturbance and treatment advances in acute pancreatitis
10.3969/j.issn.1001-5256.2014.08.033
- VernacularTitle:急性胰腺炎微循环障碍的发生机制及其治疗进展
- Author:
Fei HOU
;
Ruixia LIU
;
Chenghong YIN
- Publication Type:Journal Article
- Keywords:
acute pancreatitis;
microcirculation;
anatomy;
pathologic processes;
chemokines;
therapeutics;
review
- From:
Journal of Clinical Hepatology
2014;30(8):817-820
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,there has been increasing evidence that microcirculatory disturbance,including vasoconstriction,shunting,inad-equate perfusion,increased blood viscosity,and coagulation,is closely associated with the pathogenesis of acute pancreatitis (AP).These processes may be exacerbated by ischaemia-reperfusion injury and the generation of oxygen radicals.The anatomical features of pancreatic microcirculation,the pathophysiological mechanism of pancreatic microcirculation disturbance and related inflammatory mediators,and pro-gress in the treatment of microcirculatory disturbance in AP are reviewed.It is suggested that the pancreatic and systemic microcirculation may play a key role in the development and progression of AP.
