The role of intestinal endotoxemia in liver failure and its complications
10.3969/j.issn.1001-5256.2014.08.036
- VernacularTitle:肠源性内毒素血症在肝衰竭发生发展中的作用
- Author:
Fangyuan GAO
;
Xianbo WANG
- Publication Type:Journal Article
- Keywords:
liver failure;
endotoxemia;
pathogenesis;
hepatic encephalopathy;
peritonitis;
hepatorenal syndrome;
review
- From:
Journal of Clinical Hepatology
2014;30(8):827-830
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have found that endotoxin not only activates immune response,exacerbates liver injury,and induces liver failure, but also plays an important role in the development of hepatic encephalopathy,hepatorenal syndrome,spontaneous bacterial peritonitis,and other fatal complications.The recent progress in research on the pathogenesis of intestinal endotoxemia (IETM)and its impact on the devel-opment and progression of liver failure is reviewed and summarized.It is suggested that seeking effective methods to prevent and control IETM holds promise as the key to treating severe liver disease and liver failure successfully.
