Effect of splenectomy plus pericardial devascularization on coagulation function in patients with cirrhotic portal hy-pertension
10.3969/j.issn.1001-5256.2014.12.024
- VernacularTitle:脾切除贲门周围血管联合术对肝硬化门静脉高压症患者凝血功能的影响
- Author:
Zhenning YU
;
Lin YANG
;
Jianguo LU
- Publication Type:Journal Article
- Keywords:
liver cirrhosis;
splenectomy;
hypertension,portal;
platelet count;
hemodynamics
- From:
Journal of Clinical Hepatology
2014;30(12):1334-1336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine platelet count (PLT),mean platelet volume (MPV),and hemodynamic changes in patients with cir-rhotic portal hypertension (CPH)post splenectomy plus pericardial devascularization (SPPD),and to assess the surgical effect on coagula-tion function.Methods A retrospective analysis was performed on 83 CPH patients undergoing SPPD in our hospital from January 2008 to December 2012.Results Compared with preoperative levels,postoperative portal venous pressure decreased,blood flow was reduced,and portal vein diameter was significantly reduced;additionally,postoperative hepatic artery diameter was increased,and hepatic artery blood flow increased.Blood alanine aminotransferase,albumin,total protein,and fibrinogen levels,thrombin time,and MPV did not significantly change 30 days postoperatively versus 7 days preoperatively(P>0.05 );the corresponding total bilirubin,activated partial thromboplastin time and prothrombin time relatively declined(P<0.05),whereas PLT and prothrombin time activity increased(P<0.05).There was a significant increase in PLT (P<0.05)but no significant change in MPV 30 days postoperatively versus 7 days preoperatively (P>0.05). Conclusion SPPD can significantly improve liver functional reserve and coagulation function in patients with CPH.
