Diagnosis and treatment of acute kidney injury in patients with cirrhosis
10.3969/j.issn.1001-5256.2014.12.030
- VernacularTitle:肝硬化患者急性肾损伤的诊断与治疗
- Author:
Junjun CAI
;
Tao HAN
- Publication Type:Journal Article
- Keywords:
liver cirrhosis;
acute kidney injury;
hepatorenal syndrome;
diagnosis;
review
- From:
Journal of Clinical Hepatology
2014;30(12):1352-1356
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury is a common complication in patients with cirrhosis.It is characterized by a sudden drop in glomerular filtra-tion rate,retention of metabolic waste products,water-electrolyte imbalance,and acid-base disturbance.It markedly increases mortality in cirrhotic patients.Therefore,early diagnosis and treatment of acute kidney injury are essential to reduce mortality and improve prognosis. The development of the diagnostic criteria for acute kidney injury,the clinical application of new biomarkers of renal function such as cystatin C,kidney injury molecule-1 ,and neutrophil gelatinase-associated lipocalin,and the management of acute kidney injury in cirrhotic pa-tients are reviewed.Although creatinine test and monitoring of urinary output have their disadvantages,they remain the main diagnostic crite-ria for acute kidney injury.Development of new biomarkers for clinical use and elucidation of the underlying mechanisms of acute kidney in-jury have become a hotspot of basic and clinical research.
