Role of PI3 K/Akt/mTOR signaling pathway in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2014.09.029
- VernacularTitle:PI3K/Akt/mTOR信号转导通路在肝细胞癌发生发展中的作用
- Author:
Yuan YU
;
Xiaorong CHEN
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
adaptor proteins,signal transducing;
review
- From:
Journal of Clinical Hepatology
2014;30(9):954-957
- CountryChina
- Language:Chinese
-
Abstract:
Phosphatidylinositol 3-kinase,Akt,and the mammalian target of rapamycin (PI3K/Akt/mTOR)signaling pathway is shown to play a key role in the tumorigenesis,proliferation,metastasis,apoptosis,and angiogenesis of hepatocellular carcinoma (HCC)by regulating gene expression.The components and functions of PI3K/Akt/mTOR signaling pathway are briefly described,and the research advances in the action mechanism of PI3K/Akt/mTOR signaling pathway in the progression of HCC and related inhibitors are reviewed.It is disclosed that blocking the PI3K/Akt/mTOR signaling pathway may become a new therapy for HCC.
