Research progress in mechanism of coexistence of HBsAg and HBsAb in patients with HBV infection
10.3969/j.issn.1001-5256.2014.04.023
- VernacularTitle:HBV感染者HBsAg和抗-HBs双阳性发生机制
- Author:
Meixin REN
;
Qinghua MENG
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
hepatitis B surface antigens;
review
- From:
Journal of Clinical Hepatology
2014;31(4):375-378
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B surface antibody (HBsAb)is formed in response to hepatitic B virus (HBV)infection,which is a typical character-istic of virus clearance.It is theoretically impossible to detect sequential expression of hepatitis B surface antigen (HBsAg)and HBsAb in the same patient.In recent years,however,cases of coexistence of HBsAg and HBsAb have been frequently reported.Clinically,coexis-tence of HBsAg and HBsAb is commonly seen in patients with chronic hepatitis B and those injected with hepatitis B vaccine or given high-dose monoclonal anti-HBs.The mechanism of this special phenomenon remains unclear.The relevant research findings in China and the rest of the world are summarized.Analysis shows that coexistence of HBsAg and HBsAb may be related to HBV S gene mutation,decreased binding force of HBsAb,etc.
