Research advances in circulating miRNAs for diagnosis of hepatobiliary diseases
10.3969/j.issn.1001-5256.2014.09.032
- VernacularTitle:循环miRNA在肝胆疾病诊断中的研究进展
- Author:
Xiaofang PENG
;
Haiying LIU
- Publication Type:Journal Article
- Keywords:
liver diseases;
biliary tract diseases;
microRNAs;
diagnosis;
review
- From:
Journal of Clinical Hepatology
2014;30(9):965-968
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs)are involved in the pathological and physiological process of life activities,and some of them exist stably and abundantly in serum,plasma,and other body fluids.Previous studies have indicated that there are significant differences in the expres-sion patterns of circulating miRNAs between patients with viral hepatitis,liver fibrosis,liver cirrhosis,hepatocellular carcinoma,drug-in-duced hepatitis,and other hepatobiliary diseases at different disease stages.Among these circulating miRNAs,some can act as novel nonin-vasive biomarkers for the early diagnosis,disease progression,and prognostic evaluation of related diseases.The latest research advances in circulating miRNAs for the diagnosis of hepatobiliary diseases are reviewed.
