Research progress in tumor-associated antigen antibodies for diagnosis of liver cancer
10.3969/j.issn.1001-5256.2014.06.025
- VernacularTitle:肿瘤相关抗原及抗体在肝癌诊断中的研究进展
- Author:
Wuchen WANG
;
Yongning ZHOU
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
antigens,neoplasm;
autoantibodies;
review
- From:
Journal of Clinical Hepatology
2014;30(6):573-576
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer is one of the most common malignant tumors in the world.The mortality of patients with liver cancer remains high e-ven with increasing progress in therapies.Early diagnosis is helpful for prolonging the survival of patients,so new biomarkers need to be ex-plored for timely diagnosis and treatment of liver cancer.The present research focuses on tumor-associated antigens (TAAs)and their cor-responding autoantibodies as serological biomarkers of liver cancer.The production of autoantibodies and the TAAs and anti-TAAs currently found in the liver cancer tissue are summarized.In addition,it is pointed out that these newly found autoantibodies have relatively high sen-sitivity and specificity for the early diagnosis of liver cancer.
