Effect of LEEP combined interferon and recombinant human interleukin-2 on CIN associated high-risk HPV
10.11904/j.issn.1002-3070.2015.03.004
- VernacularTitle:LEEP术联合干扰素及重组人白介素－2对宫颈上皮内瘤变伴高危型HPV的疗效
- Author:
Cuishuang LI
;
Hong PI
;
Jin HUANG
;
Fang BAI
- Publication Type:Journal Article
- Keywords:
Loop electrosurgical excision procedure;
Interferon;
Recombinant human interleukin -2;
Cervical intraepithelial neoplasia;
Human papillomavirus
- From:
Practical Oncology Journal
2015;(3):208-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of cervical intraepithelial neoplasia Ⅱ( CINⅡ) associated high risk HPV with LEEP combined interferon and recombinant human interleukin -2.Methods One hundred and sixty patients with CIN Ⅱwere selected during Feb.2012 and Feb.2013.The patients were random-ly divided into four groups(40 patients in each group):the control group(LEEP),group A(LEEP united with in-terferon),group B(LEEP united with recombinant human interleukin -2)and group C(LEEP united with inter-feron and recombinant human interleukin -2).TCT,colposcope examination and HPV were reviewed ,and the curative effects , postoperative complications and negative conversion rate of HPV -DNA were compared after three and six months of the treatment .Results The cure rate and negative conversion rate of HPV -DNA in group C were 92.5%and 95%,which were significantly higher than others groups ( P<0.05) after six months of treatment .The time of wound healing ,duration of vaginal discharge and bleeding time in group C were also shorter than others groups(P<0.05).Conclusion The therapeutic effect of LEEP combined with interferon and recom-binant human interleukin -2 is superior to LEEP and LEEP united interferon or interleukin -2,which is not only shorter healing time ,but also fewer complications .The therapeutic method is worthy to be applied widely .
