Significance of the expression of MMP-9 and E-cadherin in triple negative breast cancer
10.3969/j.issn.1002-3070.2014.01.004
- VernacularTitle:三阴性乳腺癌中MMP-9及E-cadherin表达的意义
- Author:
Taotao LIU
;
Mengqin SHEN
;
Dandan WANG
;
Yu ZHANG
;
Xueqing YANG
;
Dabei TANG
;
Qingyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Triple negative breast cancer;
Matrixmetalloprotein-9;
E-cadherin;
Invasion;
Metastasis
- From:Practical Oncology Journal
2014;(1):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of matrixmetalloprotein -9(MMP-9)and E-cad-herin in triple negative breast cancer ( TNBC) and its relationship with the clinicopathologic features of TNBC .To analyze the function of MMP -9 and E-cadherin in TNBC .Methods Immunohistochemical method was used to detect the expression of MMP -9 and E-cadherin in 127 cases of TNBC.Results The MMP-9 positive rate was 53.54%and E-cadherin positive grade was 32.28%in TNBC.Expression of MMP-9 was correlated with tumor size(P=0.007),histological grade(P=0.006),TNM stage(P=0.003),lymph node metastasis(P=0.000)and lymph duct invasive(P=0.000).Expression of E-cadherin was correlated with lymph node metasta-sis(P=0.016)and lymph duct invasive(P=0.015).However,they were not correlated with other factors .Con-clusion The expression of MMP -9 and E -cadherin was correlated with invasion and metastasis in TNBC , which could be an important research topic in the future studies .
