Correlations between molecular subtypes and clinical pathological features in 621 breast invasive ductal carcinoma patients
10.11904/j.issn.1002-3070.2015.01.007
- VernacularTitle:621例乳腺浸润性导管癌患者分子分型与临床病理学特征的关系
- Author:
Lili YANG
;
Xiuqing AI
;
Chunyu HE
;
Xianglu ZHU
- Publication Type:Journal Article
- Keywords:
Breast invasive ductal carcinoma;
Molecular subtype;
Clinical pathological characteristics
- From:
Practical Oncology Journal
2015;(1):34-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of breast invasive ductal carcinoma with different molecular subtypes ,and to study the relationship between molecular subtypes and clinical pathological features in Xinjiang area .Methods A total of 621 patients with IDC from January 2013 to January 2014 was classified into Luminal A type,Luminal B type,HER-2 overexpression type and Basal -like type,different molecular subtypes according to the estrogen receptor(ER),progesterone receptor(PR),epidermal growth factor receptor -2(HER-2) and Ki-67,and compared the statistics combining with the clinical pathological characteristics of IDC .Re-sults The result showed that Luminal B type accounted for 53.1%,Luminal A type,HER-2 overexpression type and Basal-like type accounted for 14.5%,15.9%,16.4%,respectively.There were significant differences between the molecular subtypes and tumor size ,histological grade ,tumor pathological stage ,the expression of ER , PR and HER-2(P<0.05 for all).There were no correlations between the molecular subtypes and age ,as well as lymph node metastasis(P>0.05).Conclusion There is a close relationship between invasive ductal carcino-ma of different molecular subtypes and clinical pathological characteristics .The molecular subtypes are beneficial to treatment guidelines for clinical individual .
