Metadherin promotes gastric carcinoma metastasis through induction of epithelial-mesenchymal transi-tion
10.11904/j.issn.1002-3070.2015.01.008
- VernacularTitle:异粘蛋白 MTDH 通过上皮质间转化 EMT促进胃癌的转移
- Author:
Lin XIA
;
Guozheng YU
;
Xiantao ZENG
;
Sheng LI
;
Yuntao BING
;
Ting LI
;
Guifang YANG
- Publication Type:Journal Article
- Keywords:
MTDH;
Epithelial-mesenchymal transition;
Gastric carcinoma
- From:Practical Oncology Journal
2015;(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between gene MTDH expression and its role in promo-ting gastric carcinoma metastasis .Methods We collected clinical specimens and cultured gastric carcinoma cell lines.By Western blotting and Real -time PCR methods,protein and mRNA levels in tissues and MTDH relation-ship with EMT were detected .Results There was 86%of patients who expressed MTDH positively and 13%of normal gastric mucosa was positive expression .The results showed that the expressive level of MTDH gene in gas-tric carcinoma was higher than in the normal tissues .The expression of MTDH was correlated with TNM stage、mi-crovascular invasion、recurrence and metastasis .The expressive level of MTDH was correlated with two epithelial mesenchymal transition markers ( E-cadherin and N-cadherin ) .Conclusion MTDH may promote gastric car-cinoma metastasis through the induction of EMT process and may be a candidate biomarker for therapeutic target .
