Current status of research on liver innate immunity
10.3969/j.issn.1001-5256.2014.09.003
- VernacularTitle:肝脏固有免疫系统研究现状
- Author:
Chuantao YE
;
Xin WEI
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
liver diseases;
immunity,natural;
immune tolerance;
hypersensitivity
- From:
Journal of Clinical Hepatology
2014;30(9):846-850
- CountryChina
- Language:Chinese
-
Abstract:
Liver innate immunity plays an important role in the defense against pathogen invasion.The mechanisms of liver innate immunity for defending against pathogen invasion are reviewed,including the special anatomical and physiological characteristics of the liver,the fea-tures of innate immune cells in the liver (liver-settled cells and cells raised from blood circulation)and their function and relationship with each other in pathogen invasion,the process of pathogen identification and effect of liver innate immune cells,and the mechanism of liver immune injury and immune tolerance.Given current research on innate immune cells and innate immune molecules in the liver,further stud-ies should be conducted to understand the connection and difference between liver innate immunity and systemic immunity,thus promoting the diagnosis and treatment of liver diseases and deeper research.
