Progress on Association between COMT Gene and Violence Behavior in Patients with Schizophrenia
10.3969/j.issn.1004-5619.2014.03.011
- VernacularTitle:COMT基因与精神分裂症患者暴力攻击行为关联性的研究进展
- Author:
Qinting ZHANG
;
Min ZHAO
;
Bin XIE
- Publication Type:Journal Article
- Keywords:
forensic psychiatry;
schizophrenia;
review [publication type];
catechol-O-methyltransferase;
violence
- From:
Journal of Forensic Medicine
2014;(3):197-201
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of violence behavior in patients with schizophrenia is higher than that in common population. Data suggest that genetic factors may play a substantial role for the etiology of the behavior. Among the particular gene polymorphisms that have been considered to be involved in vio-lence behavior, the catechol-O-methyltransferase (COMT) gene had been the focus of recent research. This article reviews the association research between COMT gene and violence behavior in patients with schizophrenia in several aspects: SNP polymorphism of COMT Val158Met and COMT Ala72Ser, haplo-type of COMT gene and DNA methylation of promoter region of COMT gene. The genetic research di-rection is presented for patients with schizophrenia.
