Development and Application of Metabonomics in Forensic Toxicology
10.3969/j.issn.1004-5619.2015.03.012
- VernacularTitle:代谢组学在法医毒理学的应用进展
- Author:
Hui YAN
;
Min SHEN
- Publication Type:Journal Article
- Keywords:
forensic toxicology;
m etabonom ics;
review [publication type
- From:
Journal of Forensic Medicine
2015;(3):219-226
- CountryChina
- Language:Chinese
-
Abstract:
Metabonom ics is an im portant branch of system biology follow ing the developm ent of ge-nom ics, transcriptom ics and proteom ics. It can perform high-throughput detection and data processing with multiple param eters, potentially enabling the identification and quantification of all sm all m etabolites in a biological system . It can be used to provide com prehensive inform ation on the toxicity effects, toxi-cological mechanisms and biom arkers, sensitively finding the unusual m etabolic changes caused by poi-son. This article mainly review s application of m etabonom ics in toxicological studies of abused drugs, pesticides, poisonous plants and poisonous anim als, and also illustrates the new direction of forensic toxi-cology research.
