Time-related Expression of IL-6、IL-8 and TNF-α Following Explosive Injury to Rabbit’s Chest
10.3969/j.issn.1004-5619.2014.02.002
- VernacularTitle:兔胸部爆炸伤后IL-6、IL-8及TNF-α的时间相关性表达
- Author:
Meng HE
;
Limin DONG
;
Xiaobin HOU
- Publication Type:Journal Article
- Keywords:
forensic pathology;
thoracic injuries;
blast injuries;
IL-6;
IL-8;
TNF-α;
rabbits
- From:Journal of Forensic Medicine
2014;(2):85-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression changes of cytokines, inter-leukin-6(IL-6), interleukin-8(IL-8), and tumor necrosis factor-α (TNF-α), and the wound time following explosive injury to rabbit’s chest. Methods The rabbit’s model of explosive injury was established. The expression levels of IL-6、 IL-8 and TNF-α in the plasma were detected by ELISA method at different wound time (0.5-12 h). Results The level of IL-6 increased at 3 h after wounding and reached peak at 6 h. The level of IL-8 increased at 1 h and reached peak at 6 h. The level of TNF-α increased at 0.5 h and reached peak at 3 h. Conclusion IL-6, IL-8 and TNF-α have a time-related expression after explo-sive injury.
